Oncology

Biomedical Research in Gynecology

Antonio Gil Moreno

Summary

During 2015, the Biomedical Research Group in Gynaecology, led by Dr. Antonio Gil Moreno, also head of the Gynaecology Service of Vall Hebron Hospital, has consolidated its structure. Dr. Gil has managed to increase the already high crosstalk between clinicians and basic and translational researchers generating a more fruitful research environment. Apart from his duties as director of the group, Dr. Gil is mostly dedicated to endometrial cancer translational and clinical research within the group. Dr. Anna Santamaria, recipient of a Miguel Servet Grant since 2014, leads the ovarian cancer research line and Dr. Xavier Santamaria is responsible together with Dr. Gil of the endometriosis research line.

As remarkable scientific achievements of 2015, we highlight the consecution of important national research grants that have allowed consolidating the ovarian cancer team, as well as maintaining the scientific track of the endometrial cancer research line. The group has established a Patient-Derived Tumor Xenograft (PDTX) Platform for Endometrial Cancer, which nowadays includes 44 PDTX models of different endometrial cancer types and grades. These models are clinically relevant for the pharmacological validation of targeted therapeutical approaches. In parallel, the group has performed a profound investment to improve diagnosis of endometrial cancer by exploring the diverse opportunities of uterine aspirates. Finally, the group has also obtained this year the important ESGO credentials for the formation of fellows in the Oncologist Gynecology and mammary pathology specialities.

Together, we are moving into a more directed research towards improving the management of endometrial and ovarian cancer patients, as well as endometriosis.

Publications

total

19^.875

impact factor

2^.839

average impact factor

Selected articles+

Authors: Altadill T, Campoy I, Lanau L, Gill K, Rigau M, Gil-Moreno A, Reventos J, Byers S, Colas E, Cheema AK.
Title: Metabolomics of Exosome-like vesicles from Uterine Aspirates and Plasma Samples of Endometrial Cancer Patients.
Reference: PLoS One. 2016 Mar 14;11(3):e0151339
Impact factor: 3.234 Quartile/Decile: Q1/D2
Authors: Pedrola N, Devis L, Llauradó M, Campoy I, Martinez-Garcia E, Garcia M, Muinelo-Romay L, Alonso-Alconada L, Abal M, Alameda F, Mancebo G, Carreras R, Castellví J, Cabrera S, Gil-Moreno A, Matias-Guiu X, Iovanna JL, Colas E, Reventós J, Ruiz A.
Title: Nidogen 1 and Nuclear Protein 1: novel targets of ETV5 transcription factor involved in endometrial cancer invasion.
Reference: Clin Exp Metastasis. 32(5):467-78. 2015. A
Impact factor: 3.491 Quartile/Decile: Q2
Authors: Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Linē A, Lipps G, Llorente A, Lötvall J, Manček-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-‘t Hoen EN, Nyman TA, O’Driscoll L, Olivan M, Oliveira C, Pállinger É, Del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O
Title: Biological properties of extracellular vesicles and their physiological functions.
Reference: J Extracell Vesicles. 4:27066. Mayo 2015. A
Authors: Cortadellas T, Córdoba O, Gascón A, Haladjian C, Bernabeu A, Alcalde A, Esgueva A, Rodriguez-Revuelto R, Espinosa-Bravo M, Díaz-Botero S, Xercavins J, Rubio IT, Gil-Moreno A.
Title: Surgery improves survival in elderly with breast cancer. A study of 465 patients in a single institution.
Reference: Eur J Surg Oncol. 41(5):635-40. 2015. A
Authors: Alonso-Alconada L, Santacana M, Garcia-Sanz P, Muinelo-Romay L, Colas E, Mirantes C, Monge M, Cueva J, Oliva E, Soslow RA,Lopez MA, Palacios J, Prat J, Valls J, Krakstad C, Salvesen H, Gil-Moreno A, Lopez-Lopez R, Dolcet X, Moreno-Bueno G, Reventos J, Matias-Guiu X, Abal M.
Title: Annexin-A2 as predictor biomarker of recurrent disease in endometrial cancer.
Reference: Int J Cancer. 2015. 136(8):1863-73. A
Impact factor: 5,085 Quartile/Decile: Q1/D2

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Main research projects

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