Oncology
Experimental Hematology
Francesc Bosch Albareda
Principal investigators Marta Crespo Maull | Researchers Pablo Abrisqueta Costa, Pere Barba Suñol, David Beneitez Pastor, Mercedes Gironella Mesa, Andrés López Hernández, Ana Marin Niebla, Margarita Ortega Blanco, Carlos Palacio García, Verónica Pons Escoll, Olga Salamero García, Amparo Santamaría Ortiz, David Valcarcel Ferreiras, Maria Teresa Vallespi Sole | Researchers in training Sabela Bobillo Varela, Eva Calpe Berdiel, Guillem Orti Pascual, Beatriz Parejo Alonso | Nursing, technical and administrative staff Elisenda Alonso Arias, Júlia Carabia Juberó, Cecilia Carmen Carpio Segura, Isabel Jiménez Bernal, Mª Julia Montoro Gómez, Mireia Olive Noguer, Bárbara Tazón Vega, Adoración Venceslá García
Summary
The Experimental Hematology group, directed by Dr. Francesc Bosch, focuses on the study of the mechanisms of pathogenesis and progression of hematological malignancies. The group also studies the ex-vivo effects and ways of action of new experimental therapeutic agents that are also tested in early clinical trials within our department. During 2015 we have used our recently described ex vivo co-culture system that mimics the favorable microenvironment found in vivo in chronic lymphocytic leukemia to pre-clinically test new agents that have entered first in human clinical trials this year in our department. Regarding the study of primary central nervous system lymphoma, we have established an in vivo orthotropic model using both cell lines and primary cells from patients and have tested several new therapeutic strategies. Finally, we are also studying new potential therapeutic options in acute myeloid leukemia, both pre-clinical and in early phase clinical trials.