CIBBIM - Nanomedicine
Functional Validation & Preclinical Research (FVPR)
Ibane Abasolo Olaortua
Team Ibane Abasolo Olaortua, Yolanda Fernández Amurgo, Laia Foradad Felip, Anabel Álvarez Mercado, Natalia García-Aranda, Sandra Mancilla Zamora, Patricia Cámara Sánchez, Anna Lechado Terradas
Summary
FVPR is a technological platform able to perform, with a scientific, technological and regulatory perspective, a complete preclinical validation of a drug candidate or nanomedicine. Furthermore, FVPR also directly leads competitive research projects, in which we deepen in the use and translation of nanomedicines for treating cancer and lysosomal storage disorders.
As for the most relevant achievements of 2015, FVPR has published works related to internal projects (Fernández et al and Gener et al) as well as those developed in collaboration with biotech companies (Rocas et al.) and research groups (Romero-Hernandez et al., Rodriguez-Carmona et al., etc.). Non-competitive incomes in 2015 (222.000 €) came from collaborative projects with the industry (4 companies), groups within VHIR (10) and additional national and international research institutions (4).
Publications
2
total
4.872
impact factor
4.872
average impact factor
Selected articles+
- Gener P, Gouveia LP, Sabat GR, de Sousa Rafael DF, Fort NB, Arranja A, Fernández Y, Prieto RM, Ortega JS, Arango D, Abasolo I, Videira M, Schwartz S Jr. Fluorescent CSC models evidence that targeted nanomedicines improve treatment sensitivity of breast and colon cancer stem cells. Nanomedicine. 2015 Nov;11(8):1883-92. IF: 6.155
- Fernández Y., Foradada L., García-Aranda N., Mancilla S., Suárez-López L., Céspedes M.V., Herance J.R., Arango D., Mangues R., Schwartz S. Jr., Abasolo I. Bioluminescent Imaging of Improved Animal Models for Human Colorectal Cancer Tumor Growth and Metastatic Dissemination to Clinically Significant Sites. J Mol Biology Mol Imaging. 2015, 2(2), id:1019. IF: Not determined yet (new journal)
- Rocas P, Fernández Y, Schwartz S Jr, Abasolo I, Rocas J, Albericio F. Multifunctionalized polyurethane–polyurea nanoparticles: hydrophobically driven self-stratification at the o/w interface modulates encapsulation stability. J Mater Chem B . 2015,3, 7604-7613. IF: 4.872
- Romero-Hernández L.L., Merino-Montiel P., Montiel-Smith S., Meza-Reyes S., Vega-Báez J.L., Abasolo I., Schwartz S. Jr., López O., Fernández-Bolaños J.G. Diosgenin-based thio(seleno)ureas and triazolyl glycoconjugates as hybrid drugs. Antioxidant and antiproliferative profile. Eur J Med Chem. 2015 Jun 24;99:67-81. IF: 3.432
- Rafael D., Doktorovova S., Florindo H.F., Gener P., Abasolo I., Schwartz S. Jr., Videira M.A. EMT Blockage Strategies: Targeting Akt Dependent Mechanisms for Breast Cancer Metastatic Behaviour Modulation. Curr Gene Ther. 2015;15(3):300-12. IF: 4.906
Main research projects
View+
- Code: DiamESTar
Title: Targeted delivery of therapeutic siRNA to Ewing sarcoma junction oncogene by traceable diamond nanocrystal antibody conjugate
Funding organization: Euronanomed. ISCiii
Partners: CNRS, Academy of Science of Czech Republic, CEA, Mablife SAS, VHIR, Bellvitge Biomedical Research Insitute
Duration, from 01/04/2015 to: 31/03/2017
Budget: 623.523,00 €: (94.501,00 €, VHIR)
PI at VHIR: Ibane Abasolo
Project coordinator: CEA
- Code: PENTRI
Title: Personalized nanomedicine for triple negative breast cancer
Funding Agency: Marató Tv3
Partners: UAB, PCB, VHIR
Duration, from: Mayo 2014 to: Abril 2017
Budget: 393.095,90 (174.000 €, VHIR)
PI at VHIR: Ibane Abasolo
Project coordinator: UAB
- Code: Lipocell
Title: Functionalized nanoliposomes for the development of therapies for intracellular-based diseases. Application to Fabry disease and homozygous familial hypercholesterolemia
Funding Agency: CIBER (CIBER-BBN, Programa de Transferencia)
Partners: CIBER-BBN (Nanomol-CSIC, UAB, PCB, Vall d’Hebron), Praxis
Duration, from: December 2014 to: November 2016
Budget: 349,939.07 € (151,601€, VHIR)
PI at VHIR: Simó Schwartz
Project coordinator: CEA
- Code: TERARMET
Title: Desarrollo de terapias para el tratamiento de enfermedades raras metabólicas congénitas
Funding Agency: RETOS-MINECO
Partners: CSIC-Nanomol, CIBER-BBN (UAB, PCB, Vall d’Hebron), Praxis, Fundació Illes Balears Ramon Llull, 3P Biopharmaceuticals SL.
Duration, from: September 2014 to: December 2017
Budget: 1,142,478.95 € (88,500 €, VHIR)
PI at VHIR: Simó Schwartz
Project coordinator: Praxis