Neurosciences
Magnetic Resonance & Neuroradiology
Alex Rovira Cañellas
Researchers Juli Alonso Farré, Alejandro Tomasello Weitz, Cristina Auger Acosta, Fco. Javier Aymerich Martínez, Deborah Pareto Onghena | Researchers in training Raquel Mitjana Penella, Silvana Isabel Sarria Estrada, Sahyly Siurana Montilva, Carles Tortajada, Nicolás Romero Florez | Nursing, technical and administrative staff Manel Alberich Jordà, Juan Fco. Corral Gámez, Silvia Gelabert Udina, Elena Huerga Núñez, Ana Maria Nieto Montoya
Summary
MRI studies with early stages multiple sclerosis patients have shown that cortical thinning and subcortical gray matter volume loss was related to the presence of juxtacortical lesions, though the cortical areas with the most marked thinning did not correspond to those with the largest number of juxtacortical lesions. Also demographic and topographic characteristics are low-impact prognostic factors, presence oligoclonal bands is a medium-impact prognostic factor, and the number of lesions is a high-impact prognostic factor.
A study from a large cohort of clinically isolated syndrome patients from our center (more than 1.000) established the value of baseline MRI in predicting the risk of conversion to multiple sclerosis and of developing significant disability as a multiparametric imaging studies in acute stroke patients confirmed that admission lesion core is associated with final infarct volume. Maximal admission lesion volume compatible with favorable outcome according to imaging modality and patient age could be set and used on admission to select candidates for endovascular procedures.
Our group participated in the REVASCAT clinical trial, which included patients with anterior circulation stroke within 8 hours after symptom onset. This study showed that stent retriever thrombectomy reduced the severity of post-stroke disability and increased the rate of functional independence. We also lead the MAGNIMS recommendations on the use of MRI in the diagnostic and monitoring process of multiple sclerosis in clinical practice