Neurosciences
Neural Development, Regeneration & Neurodegeneration
Eduardo Soriano García
Research assistant Marco Antonio Solis | Research associates Ferran Burgaya, Jesús Ureña, Marta Pascual, Alexander Fausto Ulloa, Lluis Pujadas, Tiziana Cotrufo | Researchers in training:
Daniela Rossi, Serena Mirra, Yasmina Manso, Jonatan Dorca, Mónica Pardo, Antoni Parcerisas, Cristina Roselló, Marc Hernaiz, Irene Lobon, Alba del Valle Vilchez | MSC and visiting students
Alva Ortega Gascó, Boris Bouazza Arostegui, Laura Llaó Cid, Laia Torres Masjoan, Sara Gregorio Jordan | Lab technician Ashraf Muhaisen
Summary
Throughout this year we have focused mainly on two hypotheses regarding the pathogenesis of Alzheimer’s Disease (AD) and potential therapeutic strategies: 1) Reelin is an extracellular protein crucial for brain development, which is also expressed in the adult brain. Recent studies support the relationship between Reelin and AD and we have hypothesized that by regulating metabolism Aß42, phosphorylation of Tau and synaptic plasticity in adults, the Reelin cascade may be an important regulator of brain function and plasticity in adults. We tested the hypothesis that Reelin may be protective in AD by overexpression of Reelin (Reelin-OE mice) in a model of AD (J20). The Reelin-OE/J20 mice showed decreased plaque burden and rescue of synaptic and cognitive deficits, suggesting that Reelin protects from AD pathology. 2) Some human diseases (eg, cancer), are caused by somatic mutations that alter the function of specific cells. Through exome sequencing we have tested the hypothesis that somatic mutations are present in the brain of AD. We have found a remarkable number of specific SNVS. We believe these data reveal important new molecular and genetic information to understand the mechanisms that trigger the AD and open new therapeutic avenues.
Publications
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Selected articles+
- Ros O, Cotrufo T and Soriano E.
Patterned dynamics of local exocytosis in growth cones: regulation by Netrin1and dependence on the Erk1/2 and SFK pathways.
Journal of Neuroscience. (2015), 35(13): 5156-70.
- Ulloa F, Gonzàlez-Juncà A, Meffre D, Berecheguren P., Martinez-Mármol M, Cotrufo T, Seoane J. and Soriano E.
Blockade of the SNARE protein Syntaxin 1 prevents glioblastoma tumor growth in vivo.
PLoS One. (2015), 10(3): e0119707. doi: 10.1371. IF: 3, 53.
- Bosch C, Martínez A, Masachs N, Teixeira CM, Fernaud I, Ulloa F, Perez E, Lois C, Comella JX, DeFelipe J, Merchan A and Soriano E.
FIB/SEM technology allows highthroughput 3D reconstruction of dendritic spines and synapses in GFP-traced adult-generated neurons.
Frontiers in Neuroanatomy. (2015), 9:60. doi: 10.3389/fnana.2015.00060.
- Calero M, Gómez-Ramos A, Calero O, Soriano E, Avila J, Medina M.
Additional mechanisms conferring genetic susceptibility to Alzheimer’s disease.
Frontiers in Cell Neuroscience. (2015). 9:138. doi: 10.3389/fncel.2015.00138.
- Burgaya F, Masdeu M, Armendáriz B, Soriano E and Ureña J.
New partners and phosphorylation sites of Focal Adhesion Kinase identified by Mass Spectrometry.
Biochimica et Biophysica Acta (BBA) – General Subjects. (2015), accepted.
Main research projects
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- Role of Armcx proteins in Parkinson disease
Funding organization: CIBERNED intramural grant.
Application number: 2013/08
Start date 2013 finish date 2015
Project coordinator: Eduardo Soriano García
- Lipotoxicity, Hepatic steatosis and Hepatocarcinoma
Funding organization: TV3 Marathon Foundation
Application number: 613/C/2013
Start date 2014 finish date 2016
Project coordinator: Eduardo Soriano García
- The Role Of Reelin at the Crossroads of Alzheimer’s Disease Mechanisms: Tauopathy, Amyloid Toxicity and Transmissibility
Funding organization: TV3 Marathon Foundation
Application number: 15/C/2014
Start date 2015 finish date 2018
Project coordinator: Lluis Pujadas Puigdomenech
- New approaches to Alzheimer Disease pathogenesis and therapeutics
Funding organization: MINECO, Spanish Ministry of science and Technology.
Application number: SAF2013-42445R
Start date 2014 finish date 2016
Project coordinator: Eduardo Soriano García
