Neurosciences
Neurotraumatology & Neurosurgery Research Group (UNINN)
Juan Sahuquillo
Researchers Fuat Arikan Abello, Marcelino Báguena Martínez, María Dolores de la Calzada Álvarez, Alejandro Ferré Masó, Francisco Ramón Martínez Ricarte, Dulce María Moncho Rodríguez, Francisca Munar Bauza, Miriam de Nadal Clanchet, M. Antonia Poca Pastor, Marylin Riveiro Vilaboa, Ángel Robles González, Maria Sueiras Gil, Ramón Torné, Jordi Vilalta Castan | Researchers in training Lidia Castro González, Victoria Cañas Barón, Tamara Martínez Valerde, Gemma Mur Bonet, Irina Andreea Radoi, Ángela Sánchez Guerrero, Mª Angeles Vidal Jorge | Nursing, Technical and administrative staff Mercedes Arribas Serrano, Lourdes Expósito Mozas, Olga Mestres Soler, Noelia Montoya Clemente, Joana Segura Segura
Summary
The Neurotrauma and Neurosurgery Research Unit (UNINN) has completed a study aimed to establish the reference values for brain energy metabolites and glycerol. These proposed thresholds will allow the development of a clear classification of the metabolic disturbances found in patients who suffer acute brain damage and to clarify its pathophysiology, based on microdialysis findings.
Our group has successfully established tumoral organotypic brain slice cultures to study cellular and molecular processes of the brain in vitro. New projects focused in the study of factors involved in hyperglicolysis and tumor proliferation in malignant brain gliomas are showing promising results.
An additional study was conducted in collaboration with The Institute of Photonic Sciences (ICFO) in which we have monitored through medical optics non-invasive techniques the brain metabolism and the regional cerebral blood flow in patients without brain pathology. It is an important step to validate this monitoring system in order to test its future application in neurocritical care.
We have begun the inclusion of patients with traumatic brain injury (TBI) in the CENTER-TBI project (https://www.center-tbi.eu) whose aim is to improve the care for patients with TBI.
The UNINN’s first project focused on the identification of serum and neuroradiological biomarkers for diagnosis and outcome prediction in mild TBI is approaching its end. It is showing promising results and will motivate the design of future clinical and translational studies in concussion.
Our group has collaborated in the awarded study conducted by the Gene Expression and Cancer Group at Vall d’Hebron Institute of Oncology (Dr. J Seoane) which has demonstrated that the presence of a brain tumor, and also its genetic profile and response to treatment can be determined through a liquid biopsy technique.
Publications
19
total
55.171
impact factor
2.904
average impact factor
Selected articles+
- De Mattos-Arruda L, Mayor R, Ng CK, Weigelt B, Martínez-Ricarte F, Torrejon D, Oliveira M, Arias A, Raventos C, Tang J, Guerini-Rocco E, Martínez-Sáez E, Lois S, Marín O, de la Cruz X, Piscuoglio S, Towers R, Vivancos A, Peg V, Cajal SR, Carles J, Rodon J, González-Cao M, Tabernero J, Felip E, Sahuquillo J, Berger MF, Cortes J, Reis-Filho JS, Seoane J. Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma. Nature communications 2015 Nov 10;6:8839 (PMID: 26554728; FI: 11,470)
- Martínez-Valverde T, Vidal-Jorge M, Martínez-Saez E, Castro L, Arikan F, Cordero E, Radoi A, Poca MA, Simard JM, Sahuquillo J. Sulfonylurea receptor 1 in humans with post-traumatic brain contusions. Journal of Neurotrauma 2015 Oct 1;32(19):1478-87 (PMID: 26398596; FI: 3,714)
- Martínez-Valverde T, Vidal-Jorge M, Montoya N, Sánchez-Guerrero A, Manrique S, Munar F, Pelegri MD, Poca MA, Sahuquillo J. Brain Microdialysis as a Tool to Explore the Ionic Profile of the Brain Extracellular Space in Neurocritical Patients: a Methodological Approach and Feasibility Study. Journal of Neurotrauma 2015;32(1):7-16 (PMID: 25019674; FI: 3,714)
- Maas AI, Menon DK, Steyerberg EW, Citerio G, Leck F, Manley GT, Hill S, Legrand V, Sorgner A, on behalf of the CENTER-TBI Participants and Investigators. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): A Prospective Longitudinal Observational Study. Neurosurgery 2015;76:67–80 (PMID: 25525693; FI: 3,617)
- Arikan F, Vilalta J, Torne R, Noguer M, Lorenzo-Bosquet C, Sahuquillo J. Rapid resolution of brain ischemic hypoxia after cerebral revascularization in Moyamoya disease. Neurosurgery 2015 Mar;76(3):302-12 (PMID: 25584958; FI: 3,617)
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Main research projects
View+
- Identification of mutated and non-mutated tumor-associated antigens in glioblastoma. GAPVAC – Preclinical part (Nº EudraCT 2013-002801-71)
Funding organisation: European Commission. Seventh Framework Programme
Reference: GAPVAC_FP7HEALTH2012
Start date 2012 finish date 2017
IP: Juan Sahuquillo
- Collaborative European Neurotrauma effectiveness research in TBI: a prospective longitudinal observational study (CENTER-TBI)
Funding organisation: European Union FP 7th Framework program
Reference: CENTER-TBI_FP7-2013
Start date 2015 finish date 2017
IP: Juan Sahuquillo
- Structural lesions and neuropsychological repercussions in mild traumatic brain injury
Funding organisation: Fondo de Investigación Sanitaria
Reference: PI13/02397
Start date 2014 finish date 2016
IP: M Antònia Poca
- Brain repair after stroke: Magnetic field-mediated stem cell migration
Funding organisation: Fundació La Marató de TV3
Reference: 479/C/2012
Start date 2013 finish date 2016
Project coordinator: Sahuquillo. Hospital Universitari Vall d’Hebron, Barcelona; Sara García Gil-Perotin. Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de València, Valencia; Luis Martí Bonmatí. Hospital Universitari i Politècnic La Fe, Valencia
- Molecular mechanisms involved in the genesis of the glioma and study of the tumoral stem cells. Identification of new therapeutic targets and markers for the stratification in patients and response to drugs
Funding organisation: Asociación Española contra el Cancer
Reference: AECC-GE2010-07
Start date 2011 finish date 2015
IP: Juan Sahuquillo. Project coordinator: Seoane (VHIO)
